Allergome database

Allergome logo

Introduction

The Allergome hosts now information useful for all professionals in the field of allergens, including biochemists, molecular biologists, clinical allergists, epidemiologists, basic researchers including those involved in animal models. The Allergome is not only dealing with human diseases. Data on allergens relevant for veterinary allergists are marked within the same page dedicated to humans. In order to summarize for the Allergome user all the info shown on each allergen page, the allergenicity scoring system has been created. It shows results in each allergen page by a very simple graphical interface (11 coloured dots). The same data used to categorize the allergen and produce the allergenicity score are also used for a very advanced search engine. At any time the Allergome user is able to retrieve the allergenic molecule lists which have been characterized at the desired search level.

Tools

With the aim of improving the way to search the Allergome, the RefArray search engine has been developed. RefArray gives the Allergome user the chance to have a cross sectional view on Allergome data. Along with the RefArray, other web Allergome resources like the ReTiME database, the AllergomeAligner, and the AllergomeConsumer, or the local software like InterAll, the Allergome cross-linked electronic record for allergic patients, have been released. All these tools transformed the original Allergome repository for allergenic molecules in a real web-based platform. It is a new way to be informed, to inform, and to generate knowledge. For that, several important studies have been run in cooperation with the Allergome, all documented in the literature and with links in the Allergome home page. Some studies are still running and some have just started. Starting January 2011 the Allergome is cross-referenced by the Uniprot Knowledgebase, the largest protein repository worldwide. The Uniprot is used to retrieve highly homologous proteins which, flagged in the Allergome as in silico generated, expand our understanding on allergens through data generated by scientists outside the allergy field.

Impact

As time passed by the Allergome has attracted increasing interest worldwide. During the last 12 months almost 15,000 unique visitors from 140 Countries visited the Allergome at least once. The Allergome has been cited in 212 papers during the time and almost other 100 used it, though without citing the Allergome as the source. For that we kindly ask users to follow the Creative Commons License rules.

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