From Universidade de Trás-os-Montes e Alto Douro (PT)
The ValorizeByProducts project aims to enhance the by-products of through its use in the form of supplements as co-adjuvants in the prevention or treatment of obesity. The project also aims to reduce the amount of waste associated with Brassicas crops and associated costs.
By-products resulting from the agri-food industry are normally treated as industrial waste, representing large quantities of by-products with negative economic and environmental impacts. For this reason, in recent years, research has focused on transformation of by-products generated in the processing of fruits and vegetables in various value-added products. By-products resulting from the harvest of plants of the genus Brassica (kale, broccoli, cauliflower …) can be a good source of bioactive compounds. These by-products could be explored and used as extracts with biological potential activity for prevent or delay the onset of various pathologies related with obesity.
The VALORIZEBYPRODUCTS Project [Ref No. 029152, is funded by the Portuguese Foundation for Science and Technology and co-financed by the European Regional Development Fund (ERDF) through COMPETE 2020 – Operational Competitiveness and Internationalization Program (POCI)] is coordinated by Professor Eduardo Rosa at UTAD (Universidade de Trás-os-Montes e Alto Douro).
In a first task, an extract will be obtained from by-products of Brassicas (stems and leaves) and the the amount of glucoraphanin / sulforaphane present will be quantified. These results will be passed to CNC (Center of Neurosciences and Cell Biology) at the University of Coimbra, namely the MitoXT (Mitochondrial Toxicology and Therapeutics Experimental) group, coordinated by Dr. Paulo Oliveira. This group participates in the project by evaluating the cellular and mitochondrial toxicity of various broccoli extracts, while assessing whether any of these extracts have a protective effect against in vitro cell models. Later pharmacokinetic studies will be carried out in rodents and the most promising doses of BBE without toxicity will be tested in an animal model of obesity in order to validate its use. The anti-obesity actions will be evaluated in mice subjected to a diet high in fat and sugar.
For more information, please contact Eduardo Rosa ([email protected])
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