BACCHUS Publications
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Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extractsAntonio González-Sarrías and colleagues from CEBAS-CSIC and the Catholic University of San Antonio(ES) have examined factors contributing to ellagic acid bioavailability in order to evaluate whether this can be improved … read more |
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Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells—A ReviewResearchers at Ghent University (BE) have reviewed the literature describing the Caco-2 cell models for testing the bioactive properties of anthocyanins and their beneficial health effects in humans … read more |
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Time Course Production of Urolithins from Ellagic acid by Human Gut MicrobiotaGarcia-Villalba and colleagues from CEBAS-CSIC (ES) have conducted a study using detailed experiments in vitro and in vivo to identify the intermediary and final catabolites of ellagic acid in the human gut … read more |
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Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesisChristina W. A. Moyle and colleagues from the Institute of Food Research (IFR, UK) have demonstrate for the first time that VEGF is a key molecular target for specific polyphenols found in tea, apples and … read more |
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Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin productionMaria Romo-Vaquero and colleagues from the CEBAS-CSIC (ES) have examined the role of Gordonibacter and other human gut bacteria in human health … read more |
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Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So FarJuan Carlos Espín and colleagues from CEBAS-CSIC (ES) have reviewed literature describing urolithin metabolites production by gut microbiota, their absorption, tissue distribution and pharmacokinetics, and … read more |
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Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health StatusFrancesco Tomás-Barberán and colleagues from CEBAS-CSIC(ES) have described three phenotypes for urolithin production, after intake of ellagitannin and ellagic acid. The proposed phenotypes could explain inter-individual variability … read more |
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Inhibition of VEGF Signaling by Polyphenols in Relation to Atherosclerosis and Cardiovascular Disease in Recent Advances in Polyphenol ResearchRebecca Edwards and Paul Kroon with colleagues from the Institute of Food Research (UK) have reviewed the literature describing the potential for polyphenols to influence atherosclerosis … read more |
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Validated Method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extractsRocio Garcia-Villalba and colleagues from CEBAS-CSIC (ES) have developed a new method for the analysis of the extractable and non-extractable ellagitannins, based on the quantification of acid hydrolysis products … read more |
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Nutrition and health claims in practiceJudith Buttriss, Director General at the British Nutrition Foundation (UK) describes progress with implementation of the EU nutrition and health claims process, which covers all foods, drinks and dietary supplements sold in the EU and was established to ensure that claims about the nutritional or health attributes of products are substantiated by robust scientific evidence and can be relied upon by consumers … read more |
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The cardiovascular benefits of dark chocolateAsimina Kerimi and Gary Williamson from the University of Leeds (UK) have found that human intervention studies analysing chocolate consumption are complicated by metabolic dysfunction amongst participants and limited molecular knowledge of flavanols. Their review concluded that future research on chocolate should focus on the effects of individual components on human health … read more |
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Bioactive Peptides in Cereals and Legumes: Agronomical, Biochemical and Clinical AspectsArrigo F. G. Cicero and colleagues from the Departments of Life Quality Studies, Agricultural Sciences and Medicine and Surgery from Alma Mater Studiorum University of Bologna (IT) have conducted a review examining approaches for assessing effects of bioactive peptides from cereals and legumes. They determined that the best in vivo methods used activity-guided fractionation, where separation of protein-digested fractions is combined with an evaluation of specific biological activity in vivo … read more |
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Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patientsMaria Nunez-Sanchez and colleagues from Quality, Safety and Bioactivity of Plant Foods (Campus de Espinardo, ES) and the Nutrition, Digestion, Surgery and Anatomical Pathology Services (Hospital Reina Sofia, Murcia, ES) found that colorectal cancer cells taken from patients who had consumed pomegranate extract (PE) contained bioactive polyphenols, such as ellagic acid (EA) and urolithins … read more |
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Lunasin in wheat: A chemical and molecular study on its presence or absenceGiovanni Dinelli and colleagues from Alma Mater Studiorum University of Bologna (IT), Bioaesis (IT) and Kamut International (USA) have confirmed there is no lunasin, nor any lunasin-like compound(s) with similar molecular weight(s), present in various wheat genotypes … read more |
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Optimisation of a simple and reliable label-free methodology for the relative quantitation of raw pork meat proteinsMarta Gallego and colleagues from Instituto de Agroquímica y Tecnología de Alimentos (CSIC) (ES) have developed a rapid, simple, and reliable method to quantify changes in protein abundance in meat. This method will help identify bioactive proteins with potential health benefits. Proteomics is the study of the entire complement of proteins that is or can be expressed by a cell, tissue or organism … read more |
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Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestionElizabeth Escudero, Leticia Mora, Fidel Toldrá from Instituto de Agroquímica y Tecnología de Alimentos (CSIC, ES) have confirmed that peptides from dry-cured Designation of Origin of Teruel ham (D.O. Teruel, Spain) are stable after processing and digestion, and retain powerful Angiotensin I-converting enzyme (ACE) inhibitory activity. Dietary proteins can help maintain or improve health following processing or digestion … read more |
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Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2The Polyphenols and Health Group, led by Dr Paul Kroon, from the Institute of Food Research (UK), and Ana Cerezo from Nutrición y Bromatología, Facultad de Farmacia (Universidad de Sevilla, ES) have shown that some polyphenols bind directly with vascular endothelial growth factor (VEGF), which inhibits atherosclerosis and, therefore, progression of cardiovascular disease (CVD) … read more |
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Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-2 cell monolayerMarta Gallego and colleagues from the Instituto de Agroquímica y Tecnología de Alimentos (CSIC, ES) and the Ghent University (BE) have examined the stability of naturally occurring angiotensin converting enzyme (ACE)-inhibitors in dry-cured ham during intestinal trans-epithelial transport using a Caco-2 cell monolayer…read more |
Peer Reviewed Publications
González-Sarrías et. al. (2017), Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial, Molecular Nutrition and Food Research, 2017, DOI: 10.1002/mnfr.201600830, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201600830/abstract
González-Sarrías A. et. al. (2017), Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism, Eur J Nutr. 2017 Mar; 56(2): 831-841, DOI: 10.1007/s00394-015-1131-7-015-1131-7 , http://link.springer.com/article/10.1007%2Fs00394-015-1131-7
González-Sarrías A. et. al. (2017), Neuroprotective effects of bioavailable polyphenol-derived metabolites against oxidative stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, J. Agric. Food Chem. 2017, 65, 752-758, DOI: 10.1021/acs.jafc.6b04538, http://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b04538
Kardum N. et. al. (2017), Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies, International Journal of Food Sciences and Nutrition Published online: 01 Feb 2017, Doi:10.1080/09637486.2017.1283682,http://www.tandfonline.com/doi/abs/10.1080/09637486.2017.1283682?journalCode=iijf20
Selma M. V. et. al. (2017), The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two main urolithin metabotypes that correlate with cardiometabolic risk biomarkers: comparison between normoweight, overweight-obese and metabolic syndrome subjects, Clinical Nutrition, 2017, http://www.clinicalnutritionjournal.com/article/S0261-5614(17)30103-6/fulltext?rss=yes
Tumova S. et. al. (2017), Transendothelial glucose transport is not restricted by extracellular hyperglycaemia, Vascular Pharmacology, 2016, 87: 219-229, http://dx.doi.org/10.1016/j.vph.2016.11.001, http://eprints.whiterose.ac.uk/107240/
Van Rymenant E. et. al. (2017), Chronic exposure to short chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells, Journal of Nutritional Biochemistry, 2017, 39: 156-168, http://www.jnutbio.com/article/S0955-2863(16)30399-0/abstract
Walker M. et. al. (2017), Health and nutrition claims – guidance, regulation and self-regulation, Nutrition Bulletin 2017, 42: 69-79, doi: 10.1111/nbu.12251 , http://onlinelibrary.wiley.com/doi/10.1111/nbu.12251/abstract
Kerimi A. et. al. (2016), At the interface of antioxidant signalling and cellular function: key polyphenol effects, Molecular Nutrition and Food Research, 60, 1770-1788, DOI: 10.1002/mnfr.201500940, http://dx.doi.org/10.1002/mnfr.201500940
Lucey A. et. al. (2016), Guidance for the design and implementation of human dietary intervention studies for health claim submissions, Nutrition Bulletin, accepted for publication , DOI: 10.1111/nbu.12241, http://onlinelibrary.wiley.com/doi/10.1111/nbu.12241/full
Selma M. V. et. al. (2016), The human gut microbial ecology associated to overweight and obesity determines ellagic acid metabolism, Food & Function, April 2016 7(4):1769-74, DOI: 10.1039/C5FO01100K, http://pubs.rsc.org/en/Content/ArticleLanding/2016/FO/C5FO01100K#!divAbstract
Toldrá F. et. al. (2016), Characterisation of the peptide profile of Spanish Teruel, Italian Parma and Belgian dry-cured hams and its potential bioactivity, Food Research International, 2016, 89, 638-646, http://www.sciencedirect.com/science/article/pii/S0963996916304069
Toldrá F. et. al. (2016), Peptidomics as a tool for quality control in dry-cured ham processing, Journal of Proteomics, 2016, 147, 98-107 http://www.sciencedirect.com/science/article/pii/S1874391916300422
Tomas-Barberan F. A. et. al. (2016), Urolithins, the rescue of ‘old’ metabolites to understand a ‘new’ concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status, Molecular Nutrition and Food Research 2017, 61, 1, DOI: 10.1002/mnfr.201500901, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500901/abstract
Tomas-Barberan F. A. et. al. (2016), Interactions of gut microbiota with dietary polyphenols and consequences to human health, Curr. Opin. Clin. Nutr. Metab. Care, DOI: 10.1097/MCO.0000000000000314, http://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2016&issue=11000&article=00012&type=abstract
Buttriss J. et. al. (2015), Nutrition and health claims in practice, Nutrition Bulletin, 40, 211–222. , DOI: 10.1111/nbu.12155, http://onlinelibrary.wiley.com/doi/10.1111/nbu.12155/abstract
Garcia-Villalba, R. et al. (2015), Validated method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts, Agric. Food Chem., 63(29): 6555–6566
Gonzalez-Sarrias A. et al. (2015), Identifying the limits for ellagic acid bioavailability: a crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts, J. Functional Foods, 19: 225-235
Grootaert C. et al. (2015), Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health, Nutrients, 7: 1-28
Kamiloglu S. et. al. (2015), Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells – A Review, Int. J. Mol. Sci. 2015, 16(9), 21555-21574, doi:10.3390/ijms160921555, http://www.mdpi.com/1422-0067/16/9/21555
Kamiloglu S. et al. (2015), Anthocyanin Absorption and Metabolism by human Instestinal Caco-2 Cells – A Review, Int. J. Mol. Sci, 16(9): 21555-21574
Kerimi A. et. al. (2015), The cardiovascular benefits of dark chocolate, Vascular Pharmacology, 2015, 71, Pages 11–15, doi:10.1016/j.vph.2015.05.011, https://doi.org/10.1016/j.vph.2015.05.011
Kronic Ristic A. et. al. (2015), Modulation of platelet function with dietary polyphenls – A promising strategy in the prevention of cardiovascular disease, Agro Food Industry Hi Tech; 2015;26(2):16-19, http://old.teknoscienze.com//Contents/Riviste/Sfogliatore/AF2_2015/index.html#16
Mora L. et al. (2015), A peptidomic approach top study the contribution of added casein proteins to the peptides profile in Spanish dry-fermented sausages, International Journal of Food Microbiology (special issues for meat symposium), 212: 41-48
Romo-Vaquero M. et al. (2015), Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production, J. Functional Foods, 17: 785-791
Cicero A. et. al. (2014), Bioactive peptides in cereals and legumes: Agronomical, biochemical and clinical aspects, Int J Mol Sci. 2014 Nov; 15(11): 21120–21135, doi: 10.3390/ijms151121120, https://dx.doi.org/10.3390%2Fijms151121120
Espin J. C. et. al. (2014), Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients, Molecular Nutrition and Food Research. Mol. Nutr. Food Res. 2014, 00, 1–13 Accepted Feburary 2014, DOI: 10.1002/mnfr.201300931, http://www.sciencedirect.com/science/article/pii/S0308814613018074
Kroon P. A. et. al. (2014), Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research. Mol. Nutr. Food Res. 2015, 59, 401-412, doi: 10.1002/mnfr.201400478, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201400478/abstract
Toldrá F. et. al. (2014), Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion, Food Chemistry, 2014, 161, 305-311, doi:10.1016/j.foodchem.2014.03.117, https://doi.org/10.1016/j.foodchem.2014.03.117
Tomás-Barberán F. A. et al. (2014), Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status, Agric. Food Chem., 62(28): 6535-6538
Edwards R. L. et al. (2013), Inhibition of VEGF signalling by polyphenols in relation to atherosclerosis and cardiovascular disease, Recent Advances in Polyphenol Research IV, DOI: 10.1002/9781118329634.ch9
Dinelli G. et. al. (2013), Lunasin in wheat kernels: a chemical and molecular study on the absence or presence of the peptide, Available online 27th November 2013: Published Food Chemistry, Volume 151, 15 May 2014, Pages 520-525, doi:10.1016/j.foodchem.2013.11.119, http://www.sciencedirect.com/science/article/pii/S0308814613018074
Tomás-Barberán F. A. et al. (2013), Biological significance of urolithins, the Gut Microbial Ellagic Acid-derived metabolites: the evidence so far, Evidence-Based Complementary and Alternative Medicine, 2013: http://dx.doi.org/10.1155/2013/270418
Tomás-Barberán F. A. et al. (2013), Time Course Production of Urolithins from Ellagic acid by Human Gut Microbiota, Agric. Food Chem., 61(37): 8797–8806
Book Chapter
Tomas-Barberan F. A. et. al. (2016), Gut microbiota metabolism, bioavailability and health benefits of pomegranate ellagitannins-derived urolithins, Pomegranate: Chemistry, Processing and Health, ISBN 978-1-63485-687-4, https://www.novapublishers.com/catalog/product_info.php?products_id=59141&osCsid=263867d043ef481530fa3926c86a39b3
Other Dissemination Activities
Toldra F. et al. (2015), 2nd International Symposium on Fermented Meat, Intl. J. Food Micro., 212: 1 doi:10.1016/j.ijfoodmicro.2015.06.007
