Pomegranate juice and cholesterol « BACCHUS

Pomegranate juice and cholesterol

Read the following text and test your understanding on the questions below.

The application

Proposed wording

Pomegranate juice helps maintain cholesterol and lipids levels.


Specific polyphenols punicalagin and ellagic acid, found in pomegranate juice were identified as having the beneficial effect on health

Beneficial effect

Maintenance of normal cholesterol and lipid levels in the blood.

Scientific substantiation

A number of references provided but many of these addressed topics other than polyphenols in pomegranate/pomegranate juice and the claimed effect. These include narrative reviews on polyphenols, food composition, and human studies investigating the effects of polyphenols on anti-angiogenic potential, angiotensin converting enzyme activity, blood pressure, lipid oxidation, oxidative stress, platelet aggregation, or in relation to cancer prevention.

An uncontrolled intervention pilot study in 22 diabetic subjects was included where 40g of concentrated pomegranate juice was consumed per day for eight weeks and measures of cholesterol and other blood lipids were taken. These found significant changes in cholesterol and some other blood lipids.


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Question 3

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Question 5

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Question 6

What do you think about the level of evidence provided for the scientific substantiation?

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  • Were randomized controlled trials (RCTs) in humans included
  • Were the studies performed with the product/compound of interest?
  • Were the measures of the health effect valid?
  • Was there a dose-response relationship?
  • Was there evidence provided for a mechanism by which the product/component has the effect?

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Question 7

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